The chart showing pdf series, word series, html series, scan qr codes. Copy of dentinogenic ghost cell tumor ready dental implant. To the best of our knowledge, only 88 cases of dgct have been reported in the literature from 1968 to 2014. Calcifying cystic odontogenic tumor ccot demonstrates considerable diversity in histopathology and clinical behavior. Cocs account for only 12% of all odontogenic cysts, and only 214% of them are dgcts. Most cases of ccot arise centrally within bone, but occasionally they may occur peripherally 7, 8. Predictive factors of potential malignant transformation in. At the time of writing 2016, it is still the most widely used classification system although a new revision is due to come up in 2017. Notch signaling and ghost cell fate in the calcifying cystig. Dentinogenic ghost cell tumor cheshta walia, bina kashyap, sudip roy1 departments of oral and maxillofacial pathology and 1orthodontics and dentofacial orthopedics, buraydah private dental college, buraydah, saudi arabia case report introduction the world health organization who panel of experts. Dentinogenic ghost cell tumor dgct is an uncommon locally. Dentinogenic ghost cell tumor is a rare tumor constituting only.
Dentinogenic ghost cell tumora rare case report with. The cgcoc has also been reported under a variety of other designations including keratinizing cyst, keratinizing cyst and calcifying odontogenic cyst kcoc, calcifying ghost cell odontogenic tumor, dentinogenic ghost cell odontogenic tumour, epithelial odontogenic ghost cell tumour, ghost cell cyst, calcifying ghost cell odontogenic tumour. The dentinogenic ghost cell tumor dgct is a rare benign odontogenic tumor histologically characterized by islands of odontogenic epithelium with the presence of ghost cells and dysplastic dentin at different stages of calcification. The calcifying ghost cell odontogenic cyst cgcoc was first described by gorlin et al. The existence of such a variety of terms reflects both the wide clinicopathological spectrum of the for merly named coc and the confusion regarding its cystic. The term dentinogenic ghost cell tumor dgct was retained for neoplastic type 6. It is a locally invasive neoplasm that is characterized by ameloblastomalike epithelial islands, ghost cells and dentinoid. Notch signaling is an evolutionarily conserved mechanism that enables adjacent cells to adopt different fates.
Dentinogenic ghost cell tumors dgct are very rare tumors considered as solid variants of calcifying epithelial odontogenic cysts ceoc. A transition from basaloid to ghost cells is seen in most areas which may be abrupt or gradual. The 2005 who histological classification of odontogenic tumors lays out a classification system for neoplasms and other tumors related to the odontogenic apparatus. The dentinogenic ghost cell tumor dgct is an uncommon odontogenic neoplasm, regarded as a solid variant of the calcifying odontogenic cyst coc. Comparative evaluation of expression of proliferating cell nuclear antigen in variants of ameloblastoma and ameloblastic carcinoma. It has a peak of incidence in the second and third decades, with a mean age of 30. A 41yearold chinese male visited our hospital in 20, with a 4month history of bloody purulent rhinorrhea with a peculiar smell in the right nasal cavity. Adequate surgical intervention is required for aggressive lesions like dentinogenic ghost cell tumor. Aggressive epithelial odontogenic ghost cell tumor in the. An international collaborative study group on ghost cell odontogenic tumors gathered and discussed all ghost cell lesions 19. Dentinogenic ghost cell tumor dgct, also known as odontogenic ghost cell tumor, is considered as a rare neoplastic variant of calcifying odontogenic cyst coc.
Dentinogenic ghost cell tumor odontogenic ectomesenchymal odontogenic. It is characterized by ameloblastomatous odontogenic epithelium, presence of ghost cells and dentinoid material. Gcoc was so called because of the presence of keratinized ghost. Dentinogenic ghost cell tumors dgct are uncommon neoplasms classified as solid variants of calcifying odontogenic cyst and are defined as a locally. The diagnosis and treatment of dentinogenic ghost cell. It is considered to be a solid variant of calcifying odontogenic cyst coc. Peripheral dentinogenic ghost cell tumor sushant s kamat 1, gajendra s diwakar 1, mujib br ahmed 2, prashant r shetty 3 1 department of oral pathology and microbiology, yogita dental college and hospital, khed, maharashtra, india 2 department of oral pathology and microbiology, bapuji dental college, davangere, karnataka, india 3 department of periodontology, yogita dental college and. The objectives of this retrospective study were to analyze the data from 179 cases of pilomatricoma of the head and neck and to provide information on the clinical presentation, management, and outcome in order to better familiarize the otolaryngologist with this entity. Current concepts and occurrence of epithelial odontogenic. Classified as an odontogenic carcinoma, which includes. The ghostshadow cells in the center of the islands have abundant, pale, eosinophilic cytoplasm with well defined cell borders and central clear area. Notch signaling and ghost cell fate in the calcifying.
Uniqueness and rarity of the lesion is evident from the literature. The dentinogenic ghost cell tumor comes under the spectrum of ghost cell lesions. Ghost cell odontogenic carcinoma gcoc is a rare malignant odontogenic tumor with aggressive growth characteristics. Although gcs are present in a variety of odontogenic lesions notably the calcifying cystic odontogenic tumor gcot, their nature and. Dentinogenic ghost cell tumors dgct are uncommon neoplasms classified as solid variants of calcifying odontogenic cyst and are defined as a locally invasive neoplasm, characterized by ameloblastomalike islands of aberrant keratinization of odontogenic epithelium in the form of ghost cells in association with dysplastic dentin.
Peripheral dentinogenic ghost cell tumor, journal of oral. May 10, 2014 the dentinogenic ghost cell tumor comes under the spectrum of ghost cell lesions. Shear 7 proposes the term dentinoameloblasoma because it table 1. Although gcs are present in a variety of odontogenic lesions notably the calcifying cystic odontogenic tumor gcot, their nature. The calcifying cystic odontogenic tumor or calcifying odontogenic cyst is a benign cystic neoplasm of odontogenic origin that is characterized by an ameloblastomalike epithelium and ghost cells. Dentinogenic ghost cell tumor of the peripheral variant mimicking. Peripheral dentinogenic ghost cell tumor sushant s kamat 1, gajendra s diwakar 1, mujib br ahmed 2, prashant r shetty 3 1 department of oral pathology and microbiology, yogita dental college and hospital, khed, maharashtra, india 2 department of oral pathology and microbiology, bapuji dental college, davangere, karnataka, india 3 department of periodontology, yogita dental college and hospital. Dentinogenic ghostcell tumor dgct is a rare, odontogenic neoplasm which is considered to be a solid variant of the calcifying odontogenic cyst coc with locally aggressive behavior and is. There fore, dentinogenic ghost cell tumor was applied to the neoplasm. Dentinogenic ghost cell tumor dgct is a rare, aggressive and benign odontogenic tumor that causes bone destruction and cortical expansion. According to who 2005, ghost cell odontogenic carcinoma is a malignant epithelial tumor with features of calcifying cystic odontogenic tumor or dentinogenic ghost cell tumor classified as an odontogenic carcinoma, which includes.
Ameloblastoma associated with dentinogenic ghost cell tumor. Aug 20, 2014 dentinogenic ghost cell tumor dgct is a rare, odontogenic neoplasm which is considered to be a solid variant of calcifying odontogenic cyst coc with locally aggressive behavior. Dentures or over dentures can be considered, as rehabilitation until growth is completed. Pdgct occurs in older adults most commonly in the anterior mandibular region. Ghost cell odontogenic carcinoma gcoc is extremely rare with only 30 case reports in the english literature 1. These authors preferred the term epithelial odontogenic ghost cell tumor to dentinogenic ghost cell tumor, because the latter connotes a mesenchymal tissue origin and the production of true dentin, whereas. Objective to describe the clinical presentations and management of pilomatricoma, formerly known as pilomatrixoma, of the head and neck design retrospective study setting tertiary care center patients the study included 179 patients with a diagnosis of pilomatricoma of the head and neck intervention all patients underwent surgical excision for pilomatricoma of the head and neck. The dentinogenic ghost cell tumor tajima, y ohno, j utsumi, n. Hence, patients should be treated with more radical approach and should be kept on long term follow up. The dentinogenic ghost cell tumor, journal of oral. Dentinogenic ghost cell tumor dgct is a rare, odontogenic neoplasm which is considered to be a solid variant of calcifying odontogenic cyst coc with locally. Dentinogenic ghost cell tumor dgct is an uncommon locally invasive odontogenic tumor regarded by many as a variant of calcifying odontogenic cyst. Dgct is a locally invasive odontogenic neoplasm characterised by.
Abstractdentinogenic ghost cell tumors dgct are uncommon neoplasms classified as solid variants of calcifying odontogenic cyst and are defined as a locally invasive neoplasm, characterized by ameloblastomalike islands of aberrant keratinization of odontogenic epithelium in the form of ghost cells in association with dysplastic dentin. Treatment with enucleation might lead to recurrence of this tumor. Despite of the rarity of this entity, pdgct should be included in the differential diagnosis of the gingival tumors. A unique case of a calcifying cystic odontogenic tumor. Calcifying cystic odontogenic tumor may be centrally or peripherally located, and its ghost cells may exhibit calcification, as first described by. A,axial unenhanced ct scan shows a large, poorly marginated, lobulated softtissue mass causing irregular destruction of the body of the mandible, predominantly in the right. Only 214% of coc are solid tumors and are considered to be dgcts. Dentinogenic ghost cell tumor dgct is a rare, odontogenic neoplasm which is considered to be a solid variant of calcifying odontogenic cyst. Predictive factors of potential malignant transformation. Dentinogenic ghost cell tumor dgct was first described by praetorius et al. Differentially, gcots are a group of transient tumors characterized by ghost cell presence, which comprise calcifying cystic odontogenic tumor ccot, dentinogenic ghost cell tumor dgct, and ghost cell odontogenic carcinoma gcoc, all derived from calcifying odontogenic cysts cocs. Gomes da silva w, ribeiro bartholomeu dos santos tc, cabral mg, et al. Jan 21, 2016 dentinogenic ghost cell tumor first proposed by praetorius in 1981 synonyms. Coc constitute 12% of all odontogenic tumors and 214% of coc are mainly solid tumors 1.
The neoplasm, occurring in older patients, consists of ameloblastomatous epi thelium with areas of ghost cell formation and varying amounts of dentinoid. The dentinogenic ghost cell tumor, journal of oral pathology. Notch as a possible cell differentiation factor in. Chapter 21 odontogenic and nonodontogenic tumors of the jaws introduction. Dentinogenic ghost cell tumor a neoplastic variety of. Peripheral dentinogenic ghost cell tumor kamat ss, diwakar.
Dentinogenic ghost cell tumor comprises less than 0. Calcifying ghost cell odontogenic cyst is comparatively rare in occurrence, constituting about 0. The tumor shows a wide variety of tumor development brought about by cell proliferation and differentiation as mentioned in previous studies 46. Nov 10, 2011 notch signaling is an evolutionarily conserved mechanism that enables adjacent cells to adopt different fates. The tumor consisted predominantly of ghost cells with occasional areas of dentinoid in close proximity to masses of ghost cells. Copy of dentinogenic ghost cell tumor ready dental. Hence, patients should be treated with more radical approach and should be kept on long term. Peripheral calcifying cystic odontogenic tumour of the. The extraosseous odontogenic tumors may raise diagnostic challenges due to their imitation for reactive gingival lesions. According to who 2005, ghost cell odontogenic carcinoma is a malignant epithelial tumor with features of calcifying cystic odontogenic tumor or dentinogenic ghost cell tumor. The dentinogenic ghostcell tumor dgct, a solid variant of the coc, is an uncommon odontogenic neoplasm occurring predominantly in later life. Ghost cell odontogenic carcinoma gcoc is the rare malignant counterpart of ccot and it frequently arises from malignant transformation of a recurrent ccot. Dentinogenic ghost cell tumor a neoplastic variety of calcifying odontogenic cyst. Ghost cells gcs are anucleate cells with homogeneous pale eosinophilic cytoplasm and very pale to clear central areas previous nucleus sites.
Peripheral dentinogenic ghost cell tumor kamat ss, diwakar gs. Ghost cell odontogenic carcinoma with suspected cholesterol. Dentinogenic ghost cell tumor dgct is a rare, odontogenic neoplasm which is considered to be a solid variant of the calcifying odontogenic cyst coc with locally aggressive behavior and is. Dentinogenic ghost cell tumor dgct is a rare tumorous form of calcifying odontogenic cyst and only a small number of cases have been described. Clinicopathologic analysis and syndecan1 and ki67 expression in calcifying cystic odontogenic tumors, dentinogenic ghost cell tumor, and ghost cell odontogenic carcinoma. Dentinogenic ghost cell tumor dgct is a rare, odontogenic neoplasm which is considered to be a solid variant of calcifying odontogenic cyst coc with locally aggressive behavior. Gcocs are a malignant counterpart of calcifying odontogenic cyst coc or dentinogenic ghost cell tumor dgct. The total number of central and peripheral cases reported in the english literature is 10 and although mucosal infiltration is common, peripheral origin of the neoplasm could be verified in only 3 cases. Calcifying cystic odontogenic tumor associated to odontoma e492 a painless slowgrowing tumor, that equally affects the maxilla and mandible, with predilection for the anterior region of the jaw 2,3. New tumour entities in the 4th edition of the world health.
In 1962, coc was recognized as a distinct clinicopathological entity by gorlin et al. Most of them show only faint traces of nuclear material. They are locally invasive neoplasms and their main characteristic features are ameloblastoma like odontogenic epithelial proliferation, an aberrant keratinization in the form of ghost cells and dysplastic dentin. Aug 23, 2012 the calcifying cystic odontogenic tumor or calcifying odontogenic cyst is a benign cystic neoplasm of odontogenic origin that is characterized by an ameloblastomalike epithelium and ghost cells. Dentinogenic ghost cell tumor is an extremely rare variety of cocs that exists both as central and peripheral type. The dentinogenic ghost cell tumor the dentinogenic ghost cell tumor tajima, y ohno, j utsumi, n.
Calcifying odontogenic cyst, dentinogenic ghost cell tumor, and ghost cell odontogenic carcinoma. Dentinogenic ghost cell tumor first proposed by praetorius in 1981 synonyms. Dentinogenic ghost cell tumor is a locally invasive neoplasm that forms ameloblastomalike epithelial islands associated with dyskeratosis of ghost cells and formation of atypical dentin. Odontogenic and nonodontogenic tumors of the jaws are a relatively rare and heterogeneous group of benign and malignant neoplasms, hamartomas, and other bonerelated lesions that demonstrate great variability in etiology, biologic behavior, and clinical significance. Among them, the peripheral dentinogenic ghost cell tumor pdgct is an extremely rare benign odontogenic neoplasm with up to 30 cases published in the literature. Ghost cell odontogenic carcinoma arising from calcifying. In this paper, we present a case of ccot and discuss its distinct histopathologic features in recurrence. Dentinogenic ghost cell tumor a neoplastic variety of calcifying. The results showed that tumor cells in ductal structure and. Central dgct may have a locally invasive behavior with variable rates of recurrence. The different imaging and histological denhinaria confirmed the diagnosis of a dentinogenic ghost cell tumor. Peripheral calcifying cystic odontogenic tumor pccot, also known as the extra osseous ccot.
1080 865 312 740 396 955 1191 521 1194 56 549 207 1176 59 130 1231 351 592 1214 971 235 1216 1352 97 1531 288 170 616 604 1514 220 1091 1311 861 207 284 228